New therapeutic may help drug addicts avoid future drug use

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A new therapeutic may help reverse chemical imbalances made to the brain by habitual drug use and could one day help recovering drug addicts avoid future drug use. Researchers from The University of Texas Medical Branch at Galveston developed and tested a treatment on rats and found it effective in reducing the animals' cravings. Their findings are in the Journal of Medicinal Chemistry. UTMB pharmacology and toxicology professors Jia Zhou, Kathryn Cunningham and their colleagues found that the serotonin 2C receptors in drug addicts do not work as well as they should. They designed, synthesized and pharmacologically evaluated a series of small molecule therapeutics designed to restore the weakened signaling. A serotonin 2C receptor.