Tuesday, 25 September 2018


Chemist begins new project to develop carbohydrate mimics to assist cancer therapies


Dr. Robert Britton, a GlycoNet network investigator and professor at Simon Fraser University has embarked on an ambitious project to develop carbohydrate mimics to assist cancer therapies by making them more selective in how they target and kill cancer cells.

Britton's work focuses on the binding of the antibody to the cancer cell which leads to the recruitment of Natural killer cells and results in Antibody-Dependent Cell-mediated Cytotoxicity (ADCC). ADCC is a critical mechanism underlying the clinical efficacy of therapeutic anticancer antibodies. After the cancer cell is terminated, the human body will naturally get rid of it.

Britton explains the goal of his project is to develop fucosylation inhibitors that do not transfer themselves to the antibody.

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