Chemist begins new project to develop carbohydrate mimics to assist cancer therapies
Dr.
Robert Britton, a GlycoNet network investigator and professor at Simon Fraser
University has embarked on an ambitious project to develop carbohydrate mimics
to assist cancer therapies by making them more selective in how they target and
kill cancer cells.
Britton's
work focuses on the binding of the antibody to the cancer cell which leads to
the recruitment of Natural killer cells and results in Antibody-Dependent
Cell-mediated Cytotoxicity (ADCC). ADCC is a critical mechanism underlying the
clinical efficacy of therapeutic anticancer antibodies. After the cancer cell
is terminated, the human body will naturally get rid of it.
Britton
explains the goal of his project is to develop fucosylation inhibitors that do
not transfer themselves to the antibody.
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