Scientists create synthesized antibiotic capable of treating superbugs

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A "game changing" new antibiotic which is capable of killing superbugs has been successfully synthesized and used to treat an infection for the first time -- and could lead to the first new class of antibiotic drug in 30 years.

The breakthrough is another major step forward on the journey to develop a commercially viable drug version based on teixobactin -- a natural antibiotic discovered by US scientists in soil samples in 2015 which has been heralded as a "gamechanger" in the battle against antibiotic-resistant pathogens such as MRSA and VRE.

Dr Ishwar Singh, a specialist in novel drug design and development from the University of Lincoln's School of Pharmacy, said: "Translating our success with these simplified synthetic versions from test tubes to real cases is a quantum jump in the development of new antibiotics, and brings us closer to realising the therapeutic potential of simplified teixobactins.

"When teixobactin was discovered it was groundbreaking in itself as a new antibiotic which kills bacteria without detectable resistance including superbugs such as MRSA, but natural teixobactin was not created for human use.

"A significant amount of work remains in the development of teixobactin as a therapeutic antibiotic for human use -- we are probably around six to ten years off a drug that doctors can prescribe to patients -- but this is a real step in the right direction and now opens the door for improving our in vivo analogues."